The research article Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years, investigates whether acetaminophen intake during pregnancy is related to behavioral problems assessed in early childhood. PM Based on a prospective U.S. cohort of 2,400+ mother‐child dyads, the authors measure acetaminophen intake during pregnancy and then assess at age 3 via the Child Behavior Checklist. PubMed+1 Acetaminophen is related to increased “attention problems” and increased “sleep problems” according to the Child Behavior Checklist. Moreover, authors controlled for maternal stress as a potential confounder. Findings remained significant even after the control.
Although odds ratios are modest at adjusted odds ratios for attention and sleep‐related issues in some, it's a concern, especially given how common acetaminophen is in the world among pregnant mothers. Furthermore, authors suggest that if acetaminophen is a common drug across populations for mothers, then even a small increase in risk is unjustified for exposure; However, the authors caution that this study is observational and does not support a cause/effect relationship.