Magic pill can save all kinds of cancer

Question

Researchers have developed a new drug that works against all the main types of primary bone cancer. Researchers have achieved a groundbreaking milestone in medicine by developing a revolutionary new drug that exhibits remarkable efficacy against all the main types of primary bone cancer. This significant breakthrough is a glimmer of hope for countless patients and their families grappling with the devastating impact of bone cancer. The development of this drug represents a monumental leap forward in the battle against this aggressive and often fatal disease.

Comments

According to University of Sheffield:

"But a new study published in the Journal of Bone Oncology shows how a new drug called ‘CADD522’ blocks a gene associated with driving the cancer’s spread, in mice implanted with human bone cancer.

The breakthrough drug increases survival rates by 50 per cent without the need for surgery or chemotherapy. And unlike chemotherapy, it doesn’t cause toxic side effects like hair loss, tiredness and sickness."

So it's not "saving" all kinds of cancer, it is increasing chances of survival for bone cancers only. And we still have to see it in humans, so it's only theoretical based on the mice trials.

Answer 1

According to University of Sheffield:

"But a new study published in the Journal of Bone Oncology shows how a new drug called ‘CADD522’ blocks a gene associated with driving the cancer’s spread, in mice implanted with human bone cancer.

The breakthrough drug increases survival rates by 50 per cent without the need for surgery or chemotherapy. And unlike chemotherapy, it doesn’t cause toxic side effects like hair loss, tiredness and sickness."

So it's not "saving" all kinds of cancer, it is increasing chances of survival for bone cancers only. And we still have to see it in humans, so it's only theoretical based on the mice trials.

https://www.sheffield.ac.uk/news/revolutionary-new-bone-cancer-drug-could-save-childrens-lives

Comments

I appreciate the added details of effects the drug has, it seems to be very positive!  But I'm confused because I don't see how this drug can treat every cancer if the articles only address bone cancers, and I don't think a claim like that can be made if it has only been tested on mice and not humans yet.

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Thank you for the in-depth answer! I found out from your post that they have not started testing on humans yet.

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Nice work! going in depth on the gene. As well as clearing up misleading information human testing

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The 50% figure is the true news from the post

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Nice work identifying that the claim is somewhat true, but also has a misleading aspect to it since it implies that the drug will save lives, when it hasn't yet been tested on humans. Perhaps the rating should be exaggerated/misleading?

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The added clarification on the mice trials was a nice touch. It will most likely be easier to identify the pill's effectiveness when humans are included in the trial.

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Great job adding multiple sources and explaining each one thoroughly. I liked how you added quotes from both sources as well. There were no opinions just facts given from the source. Good job!

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I enjoy the detail along with understanding that came with answering the prompt. Well done!

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It is good that you were able to identify what’s leading and what can be misleading. That you went into detail about how the mice were the actual test subjects and how a title can’t be what it reads to be.

Answer 2

The new drug called CADD522, helps to increase survival rates. The article notes that trials of the drug have only been used in laboratory models of primary bone cancer and has yet to reach human trials.

https://www.bcrt.org.uk/news/2023/march/revolutionary-new-bone-cancer-drug-identified

Comments

Yeah, it is true but the post title is exaggerated and misleading.

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I agree with what the person said above me, what you said isn't false. What you said is true but I think that the title of this article is misleading considering it has yet to reach human trials

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This response is good, it is a little vague. The answer is correct and modern medicine is helping with the probability of beating cancer. I found this out by going to your source. There could be better paraphrasing in your response, but i still got the information in the end.

Answer 3

According to the BBC:

The drug has shown significant success among mice who have been injected with human bone cancer. The current survival rate after chemo and surgery for patients with bone cancer is around 42% and with the drug CADD522 they saw a 50% increase among the mice (without needed surgery). And because most human patients will likely need surgery as well the survival rate could increase even more. That being said, the drug has only been tested on mice and has yet moved to human trials, but because the success rate among mice is as high as it is, one can hope that the human trials will go just as well.

https://www.bbc.com/news/uk-england-norfolk-64889948

Comments

The statistics in this helped me understand this more

Answer 4

In this peer-reviewed study from 2017, researchers discovered that CADD522 demonstrated inhibition of RUNX2-DNA binding. RUNX2 is a transcription factor that is known for promoting breast cancer development. They found that CADD522 could disrupt the various molecular interactions and pathways RUNX2 relied on to promote oncogenesis. The study goes on to indicate that CADD522 disrupts fundamental pathways of oncogenesis, and could potentially help combat all forms of cancer, as shown by the current research and success with bone cancer treatment. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642608/

Answer 5

Yes, there is a new drug in the works to help with bone cancer but it has not been approved yet. The new drug is called CADD522 which according to University of Sheffield, "increases survival rates by 50 per cent without the need for surgery or chemotherapy." It is primary for children and young adults between the age of 10-20. It is still being tested though and has not been approved by the government.

https://www.sheffield.ac.uk/news/revolutionary-new-bone-cancer-drug-could-save-childrens-lives#:~:text=But%20a%20new%20study%20published,need%20for%20surgery%20or%20chemotherapy.

Comments

I like how your comment was straightforward.

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How would you rate the claim? True? False? Misleading? Don't forget to add a rating to each fact-check.

Answer 6

I just recently saw something about this. This article says, "The new paper shows preclinical toxicity testing in two species (mice and dogs), which is what you need to get to human trials. It seems to pass those very well, with no signs of trouble at 6x the effective dose in either species."

https://www.science.org/content/blog-post/new-mode-cancer-treatment

Answer 7

The headline of this article leads readers to believe that this drug applies to all kinds of cancer, when the article linked only provides reason for bone cancer. Upon further research, I learned that CADD522 has only been proven to help in the field of bone cancer. In a study of mine that had been injected with human bone cancer, the CADD522 has proven to be successful in stopping the spread. 

While the article is not wrong in its claim of helping bone cancer, its headline is misleading in the idea that it can cure all kinds of cancer. 

https://www.npr.org/2022/06/07/1103545361/cancer-drug-experimental-rectal-chemotherapy-surgery-treatment-immunotherapy#:~:text=In%20a%20very%20small%20trial,one%20of%20their%20tumors%20disappearing. 

https://www.bcrt.org.uk/news/2023/march/revolutionary-new-bone-cancer-drug-identified

Answer 8

When you first start reading, it gives this statement, “But now a new study shows how a new drug called ‘CADD522’ blocks a gene associated with driving the cancer’s spread, in mice implanted with human bone cancer.” We can read that so far it has only been tested with mice that has had an implant of human bone cancer and not actual people. It does give us good feedback as it upped the survival rate 50%, but since it has only been tested on mice it isn’t accurate enough to say it is a successful for human and all types of cancer.

Comments

Do you have any source links to support the fact-check?

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The source I used for my answer was the one that was linked to the original post. With the information that was already given I did not look for any other sources since It gave us a clear description of what was used and what it initial motive was. The top comment does give a better answer with other link to clarify the original post.